N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
DDR1-IN-1
CAS: 1449685-96-4
Molecular Formula: C30H31F3N4O3
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide - Names and Identifiers
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide - Physico-chemical Properties
| Molecular Formula | C30H31F3N4O3 |
| Molar Mass | 552.59 |
| Solubility | DMSO: ≥ 41 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | In U2OS cells, DDR1-IN-1 inhibited basal DDR1 autophosphorylation with an EC50 of 86 nM and a stronger inhibition of DDR1 autophosphorylation in the absence of collagen stimulation. In a panel of different cancer cell lines with gain-of-function mutations and/or overexpression of DDR1, DDR1-IN-1 did not inhibit cell proliferation at concentrations below 10 μm, while GSK2126458 will enhance the antiproliferative activity of DDR1-IN-1. |
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.81 ml | 9.048 ml | 18.097 ml |
| 5 mM | 0.362 ml | 1.81 ml | 3.619 ml |
| 10 mM | 0.181 ml | 0.905 ml | 1.81 ml |
| 5 mM | 0.036 ml | 0.181 ml | 0.362 ml |
Last Update：2024-01-02 23:10:35
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide - Reference Information
| biological activity | DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor, with an IC50 of 105 nM, the selectivity is approximately 3-fold higher than for DDR2. |
| Target | Value |
| DDR1 (Cell-free assay) | 105 nM |
| DDR2 (Cell-free assay) | 413 nM |
Last Update：2024-04-09 20:49:11
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View History
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
2-溴-1,1,1,4,4,4-六氟-2-丁烯
NALPHA-ACETYL-D-ARGININE DIHYDRATE
2-[BENZYL(2-HYDROXYETHYL)AMINO]-1-ETHANOL
Scopoline Methobromide (Tiotropium Bromide Impurity H)
2-Buten-1-one, 1-(6,6-dimethyl-2-methylene-3-cyclohexen-1-yl)-
2,4-二甲基-5-醛基-吡咯-3-羧酸
Sintofen [iso]
异十三烷氧基丙基丙撑二胺
6-氨基环己-3-烯甲酸盐酸盐
2-溴-1,1,1,4,4,4-六氟-2-丁烯
NALPHA-ACETYL-D-ARGININE DIHYDRATE
2-[BENZYL(2-HYDROXYETHYL)AMINO]-1-ETHANOL
Scopoline Methobromide (Tiotropium Bromide Impurity H)
2-Buten-1-one, 1-(6,6-dimethyl-2-methylene-3-cyclohexen-1-yl)-
2,4-二甲基-5-醛基-吡咯-3-羧酸
Sintofen [iso]
异十三烷氧基丙基丙撑二胺
6-氨基环己-3-烯甲酸盐酸盐